Used for many medicinal purposes, black cohosh (Cimicifuga racemosa) is a perennial herb native to North America. The chief element in the black cohosh root is a substance known as cimicifugin or macrotin. Studies have shown that black cohosh contains several compounds that may contribute to its potency, including: cycloartane, triterpene glycosides (such as acetin and 26-deoxyaxtein), henylpropanoid esters, and phenolic compounds (such as caffeic acid derivatives). Black cohosh has often been used for scalp hair loss, but until EES-Essential Eyebrow Solution® was formulated, it had never been used to address thinning eyebrows. For this reason, EES was carefully tested in a preliminary, open-label, dose-ranging study. The results of the study were reported in PRIME International Journal of Aesthetic and Anti-Ageing Medicine, a professional journal of dermatology and related sciences.